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Affinity constants of BoNT/B and HcB for exoSYT2/GT1b.
| Toxin (subtype) | M W (kDa) | Activity (LD50/mg) | kon × 105 (M−1.s−1) | koff × 10−4 (s−1) | KD (nM) | n |
|---|---|---|---|---|---|---|
| BoNT/B holotoxin (B1) | 150 | 0.5 × 108 | 2.3 ± 1 | 1.3 ± 0.5 | 0.6 ± 0.1 | 6 |
| BoNT/B (B1) | 550 | 1.2 × 107 | 3.1 ± 1.2 | 4.1 ± 1.4 | 1.4 ± 0.2 | 4 |
| HcB (B2) | 50 | — | nd | <0.1 | nd | 4 |
n = independent experiments; nd = not determined; Values are mean ± SEM.
