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. 2017 Apr 25;7:1143. doi: 10.1038/s41598-017-01247-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Left: Thickness histogram for the Chol10₃₁₆ system. The inset shows the normalized cumulative distributions. Solid lines show data collected from the whole system and dashed lines data collected from locations occupied by cholesterol. Grey fill highlights regions with a small local concentration of cholesterol. Right: The proposed domain structure; DPPC chains are shown in green and cholesterol in orange. The estimated locations of lipids displaying L_o-like, L_d-like, and hexagonally packed regions are shaded with yellow, red, and blue, respectively. The simulation box is drawn in black.