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. 2017 Apr 21;7:1075. doi: 10.1038/s41598-017-00949-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cells migrate under the agarose spot containing a chemokine according to the expression of the cognate chemokine receptor. PC-3 cells which express chemokine receptors CXCR4 and CCR7 migrate under agarose spot containing ligand for CXCR4, CXCL12, (A), and ligands for CCR7, CCL21, (B) and CCL19, (C), but do not migrate under agarose spot containing no chemokine, (D). (E) Relative chemotactic aptitude of PC-3 cells under agarose spot containing 100 nM CXCL12 (ligand for CXCR4), and agarose spot containing 100 nM CCL19 and 100 nM CCL21 (ligands for CCR7), but not under agarose spot containing no chemokine (n = 3). (F) SW480 cells which express chemokine receptor CXCR4 but not CCR7, migrate under agarose spot containing 200 nM CXCL12 (ligand for CXCR4), but not under agarose spot containing 200 nM CCL19 and 200 nM CCL21 (ligands for CCR7), or agarose spot containing no chemokine (n = 3).