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. 2017 Apr 24;7:1081. doi: 10.1038/s41598-017-01167-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of expression for MIR126-5P and its target mRNAs in eCig treated human lung epithelial cells. Validation of MIR126-5P induction, and suppression of its target mRNAs by eCig liquid. Shown are fold differences in expression (log scale) for each gene upon eCig exposure. (A) MIR126-5P is highly induced by eCig liquid, particularly following vaporization. Increased expression of MIR126-5P upon CSC treatment did not reach significance. (B) Two MIR126-5P–specific target genes, MYC and GPCR, display reduced expression following treatment with e-cg liquid. Increased expression of MIR126-5P following treatment with eCig liquid resulted in decreased expression of MYC (46% in NON VAP, 31% in VAP) and MRGPRX3 (75% in NON VAP, 66% in VAP), as compared to CTL cells. ^#p < 0.05 (MWU) (vs CTL); ^#!p < 0.05 (NON VAP vs VAP) (MWU).