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. 2017 Apr 28;7:1274. doi: 10.1038/s41598-017-01305-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Melatonin, NAS, 6-OHM, AFMK, and 5-MT treated melanocytes increased NRF2 expression after UVB exposure. Melanocytes were exposed to UVB intensities of 0 or 50 mJ/cm² and immediately treated with melatonin or its derivative for 24 h. Cells were further fixed and stained with anti-NRF2 antibody. Stained cells were imaged with a fluorescence microscope, fluorescence intensity was analysed using ImageJ software, and data are analysed using Graph Pad Prizm after 0 mJ/cm² (a) and 50 mJ/cm² (b). In addition, UVB diminishes NRF2 expression (insert). Data are presented as percentile of control and were analyzed using t- test, *p < 0.05, **p < 0.01.