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. 2017 Apr 26;7:1172. doi: 10.1038/s41598-017-01178-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationships between the early expression levels of candidate genes and post-stroke BBB disruption. (A) Relationships between peripheral blood total transcriptional expression levels of each of the 16 candidate genes at hospital admission and level of HARM on perfusion-weighted imaging at 24 hour follow up. Expression levels are presented as standardized values generated from mean normalized microarray florescence intensities. Significance of relationships between gene expression levels and severe HARM was assessed via bias-reduced logistic regression. (B) Relationship between peripheral blood total transcriptional expression levels of AKAP7 at hospital admission and level of HARM on perfusion weighted imaging at 24 hour follow up. Expression levels are presented as mean normalized microarray florescence intensity and were compared between HARM categories using one-way ANOVA. (C) Receiver operator curve depicting the sensitivity and specificity of admission peripheral blood total AKAP7 levels as an identifier of patients who later developed severe HARM.