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. 2017 Apr 27;7:1217. doi: 10.1038/s41598-017-01279-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of association between T cell-associated genetic signatures and LGALS1 in human glioblastoma (GBM) patients. (A) The ratio of genetic signatures or metagenes specific for Th1 and Treg was used to stratify the The Cancer Genome Atlas (TCGA) GBM patients into “high Th1/Treg ratio” (red) or “low Th1/Treg ratio” groups; followed by Kaplan-Meier plotting of patient’s overall survival versus follow-up duration in days. (B) The ratio of genetic signatures or metagenes specific for CTLs and Treg was used to stratify the TCGA GBM patients into “high CTL/Treg ratio” (red) or “low CTL/Treg ratio” groups; followed by Kaplan-Meier plotting of patient’s overall survival versus follow-up duration in days. (C) The differential expression of LGALS1 was used to stratify the TCGA GBM patients into “high expression” (red) or “low expression” groups; followed by Kaplan-Meier plotting of patient’s overall survival versus follow-up duration in days. In A–C graphs, log-rank (Mantel-Cox) test p-values and hazard ratios (HR) with 95% confidence interval (in paranthesis) are displayed. Alternatively, a Pearson’s correlation coefficient was calculated to assess the overall association between LGALS1 expression and overall expression of either Th1/Treg ratio (D) or CTL/Treg ratio (E).