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. 2017 Apr 26;7:1171. doi: 10.1038/s41598-017-01238-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic representation of the skin structure. The dashed line corresponds to the plane of the papillary dermis cross-section measured with MPT, the outer and inner circles correspond to the cross-section of dermal papilla and the inner area around capillary. (b,c) Two-photon images of the dermal papilla: SHG and TPAEF signals, respectively. The white arrows correspond to the “hollow” area inside the papilla. (d) Spatial distribution of the SAAID index (SAAID = (SHG – TPEAF)/(SHG + TPEAF)) in the dermal papilla. (e) FLIM image of the dermal papilla, pixel colors correspond to different values of the mean fluorescence lifetime τ _m in the 100 ÷ 2000 ps range. (f) Mean lifetime distributions obtained for the outer area, positive SAAID (>0.15, collagen I) and negative SAAID (−0.4 ÷ −0.35) regions of the dermal papilla (see text for details).