Table 1.
Non-synonymous substitutions between PF13 and BE H 815744, and the distribution of these substitutions in strains from America and Asia.
| Gene | Positionb | Nucleotide substitution (aa substitution) | Nucleotide substitution; Presence/number of observed strainsa | ||
|---|---|---|---|---|---|
| H/PF13 | BE H 815744 | Asian strains | American strains | ||
| PrM | 859 | C (L) | T (F) | T; 7/7 | T; 34/34 |
| NS1 | 2908 | G (E) | A (K) | A; 7/7 | G; 1/34 - A; 33/34 |
| 3517 | A (M) | G (V) | A; 7/7 | A; 29/34 - G; 5/34 | |
| NS4B | 7990 | A (M) | G (V) | A; 7/7 | G; 34/34 |
| 3′UTR | 10374 | G | A | G; 7/7 | A; 34/34 |
aWe selected strains for which the complete genome was available in NCBI and that were collected in epidemic countries (to avoid imported cases; strains collected in China and Japan were not included) in America and Asia after 2010. See Table S3 for detail. bPosition was defined according to H/PF13.