Table 3.

Univariate and multivariate analysis for overall survival.

Variable	HR−HER2+ (n = 273)						HR+HER2+ (n = 246)
	Univariate			Multivarites			Univariate			Multivarites
	HzR	95% CI	P	HzR	95% CI	P	HzR	95% CI	P	HzR	95% CI	P
Age (years)
≤50	1.48	1.04–2.10	0.030	1.5	1.04–2.16	0.029	1.42	1.00–2.03	0.052
>50	1	ref						1	ref
DRFI (months)
≤24	1	ref					1	ref
>24	0.64	0.47–0.88	0.006	0.55	0.39–0.76	<0.001	0.53	0.38–0.75	<0.001	0.45	0.32–0.64	<0.001
NO. of metastatic sites
isolated	1	ref					1	ref
≥2	1.31	0.95–1.80	0.094	1.49	1.07–2.07	0.018	1.50	1.05–2.14	0.031	1.50	1.05–2.14	0.025
First-site of distant relapse
Nonvisceral	1	ref					1	ref
Visceral	1.6	1.14–2.25	0.006	1.51	1.07–2.12	0.019	1.14	0.81–1.63	0.450
Palliative-trastuzamb
trast−	1	ref					1	ref
trast+	0.39	0.28–0.53	<0.001	0.4	0.29–0.55	<0.001	0.43	0.31–0.61	<0.001	0.41	0.29–0.58	<0.001