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. 2017 Apr 21;7:1050. doi: 10.1038/s41598-017-01146-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Substitutions of asparagine N791. (A) Close-up view of the region encompassing noncompetitive inhibitor binding site, with N791 shown as thick (green, blue and red) and other residues thin (grey) sticks. The pore axis is illustrated by a blue cylinder. (B–D) The average values of fractions of non-desensitized channels, I _SS/I _Max and I _SS/I _Peak (B) and time constants of deactivation, τ _Deact (C) and desensitization, τ _Des (D) for wild type GluA2 and mutant receptors. Error bars represent SEMs.