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. 2017 May 2;7:1312. doi: 10.1038/s41598-017-01425-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The Retro-Inverso peptides inhibit cell migration and matrigel invasion. (a) Human fibrosarcoma HT1080 cell migration toward 10 nM fMLF or 10 nM the indicated peptides, monitored for 18 hr by the xCELLigence system Data represent mean ± SD from a quadruplicate experiment. (b,c) HT1080 cells were allowed to migrate (b) or invade matrigel (c) toward 10% FBS (None) or 10% FBS plus 10 nM of the indicated peptides in Boyden chambers for 4 hr (b) or 6 hr (c). Basal values assessed in the absence of FBS (CTRL) were taken as 100% and all values were reported relative to that. Data are the means ± SD of three independent experiments, performed in triplicate. *Statistical significance calculated against None, with *P < 0.01, **P < 0.001. (d,e) HT1080 cell migration (d) or matrigel invasion (e) toward serum-free medium (CTRL), 10% FBS without (None) or with 10 nM of the indicated peptides, monitored for 18 hr (d) or 20 hr (e) by the xCELLigence system. Data represent mean ± SD from a quadruplicate experiment.