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. 2017 May 2;7:1322. doi: 10.1038/s41598-017-01625-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of anti-rejection drugs on Tfh cell subsets. (a) CD4, CXCR5, IFN-γ, CXCR3 and CCR6 antibodies were used to detect Tfh1 cells; (b) CD4, CXCR5, IL-4, CXCR3 and CCR6 antibodies were used to detect Tfh2 cells; (c) CD4, CXCR5, IL-17, CXCR3 and CCR6 antibodies were used to detect Tfh17 cells; (d) CD4, CXCR5, ICOS, Foxp3 and CD127 antibodies were used to detect Tfh and Tfr cells; (e) The anti-rejection drugs had no significant effect on the proportion of Tfh cells in lymphocytes (LYM). (f) Cyclosporine and tacrolimus reduced the proportion of IL-21-producing Tfh cells (Tfh2 and Tfh17 cells) in lymphocytes. (g) Sirolimus could reduce the proportion of Tfr cells in lymphocytes after being stimulated for 48 hours. Student’s t test: *p < 0.05 (n = 6) versus Control. Values are mean ± SD.