Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 2;7:1424. doi: 10.1038/s41598-017-01542-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Catalytic mechanism of pAPN. (A) Overall structure of pAPN complexed with a peptide substrate (PDB 4FKF). pAPN contains four domains: head (in cyan), side (in brown), body (in magenta), and tail (in yellow). Zinc is shown as a blue ball, and the peptide substrate is in green. (B) Interactions between catalytic residues of pAPN (in magenta) and the scissile peptide bond of the peptide substrate (in green). Catalytic water is shown as a red ball. (C) Another view of the structure in panel (B) to show all of the interactions between pAPN and the N-terminal residue of the peptide substrate. (D) Interactions between catalytic residues of pAPN (in magenta) and product of APN catalysis - free alanine (in green) (PDB 4FKH). (E) Another view of the structure in panel (D) to show all the interactions between pAPN and free alanine.