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. 2017 May 3;7:1416. doi: 10.1038/s41598-017-01641-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Thalidomide specific binding to the T-box domain of TBX5. The corresponding protein-ligand interaction diagram shows the most relevant amino acid within 5 Angstroms of thalidomide. Arginine at position 81 (arrow) is proposed as the main player for the TBX5-thalidomide docking simulation. The T-box domain of TBX5 (pdbid: 2X6V) was retrieved from the Protein Database (PDB). All colored amino acids with their positions are the ones in close proximity with Thalidomide.