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. 2017 May 3;7:1453. doi: 10.1038/s41598-017-01347-6

Table 5.

Comparing incidences of toxic effects between the propensity score matched treatment group.

Pemetrexed Non- Pemetrexed P
125 pairs
Adverse events N % N %
Fatigue AE 18 14.29% 26 20.63% 0.184
SAE 0 0 0 0
Fever AE 1 0.79% 3 2.38% 0.622
SAE 0 0 0 0
Nausea AE 102 81.60% 99 79.20% 0.633
SAE 1 0.79% 6 4.76% 0.12
Vomiting AE 64 50.79% 34 26.98% <0.001
SAE 0 0 4 3.17% 0.122
Mucositis AE 2 1.59% 4 3.17% 0.684
SAE 0 0 0 0
Constipation AE 8 6.35% 5 3.97% 0.393
SAE 0 0 0 0
Rash AE 4 3.17% 0 0.00% 0.122
SAE 0 0 0 0
Alopecia AE 7 5.56% 29 23.20% <0.001
SAE 0 0 3 2.38% 0.247
WBC AE 57 45.60% 98 78.40% <0.001
SAE 4 3.17% 28 22.22% <0.001
Neutropenia AE 69 55.20% 95 76.00% 0.001
SAE 14 11.11% 56 44.44% <0.001
Anemia AE 44 35.20% 57 45.24% 0.124
SAE 0 0 0 0
Thrombocytopenia AE 21 16.67% 24 19.05% 0.622
SAE 3 2.38% 3 2.38% 1

AE, adverse event SAE, sever adverse event.