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. 2017 May 3;7:1467. doi: 10.1038/s41598-017-01561-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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KXS series formulae exerted antidepressant actions in open field tests of CUMS-treated mice. After four weeks of CUMS exposure and one week of KXS series formulae treatment, all groups of mice were employed for open field tests, including time spent in central area, rearing number and total travel distance. Fluoxetine at daily dosage of 4 mg/kg was set as the positive control. KXS series formulae treatment was set for three groups, K-652, K-984, D-652, all at 10 g/kg. Values are expressed in the percentage of non-stressed group as Mean ± SEM (n = 8). Comparisons between groups were carried out by a one-way ANOVA followed by a post-hoc Bonferroni test. ^#p < 0.05, ^##p < 0.01 (compared with non-stressed group); *p < 0.05, **p < 0.01 (compared with stressed group).