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. 2017 May 3;7:1449. doi: 10.1038/s41598-017-01202-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantitative serum and tissue proteomic analysis of SVZ+ and SVZ- GBMs. Schematic of iTRAQ based proteomic analysis of (a) serum and (b) tissue specimens for the identification of quantitative proteomic alterations. (c) Serum proteomic analysis of SVZ+ (n = 12) and SVZ- (n = 12) GBMs was performed using iTRAQ method. Representative mass spectra for one of the highly up-regulated (apolipoprotein E) and down-regulated (hemoglobin subunit beta) proteins in SVZ+ GBMs (w.r.t SVZ− GBMs). (d) Tissue proteomic analysis of SVZ+ (n = 6) and SVZ- (n = 6) GBMs was performed using iTRAQ approach. Representative mass spectra of two differentially expressed proteins, thymosin beta-4-like protein 3 and annexin A2 in SVZ+ GBM tumors (w.r.t SVZ− GBMs). Relative abundance of thymosin beta-4-like protein 3 and annexin A2 protein are shown in the inset as the intensities of iTRAQ reporter ions.