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Progression of major macromolecular events in autophagic process. mTORC‐mediated repression of autophagy is relieved by decreased nutrient availability and pro‐autophagic downstream signalling thorough ULK1 and Beclin1–PI3KC3. The lipid mediator PI3P produced by Beclin1–PI3KC3 triggers WIP12/DFCP1‐mediated assembly of the Atg12– Atg5– Atg16 complex, in turn stimulating Atg8 (LC3)‐induced progression of the degradation of targeted materials.
