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Effects of compounds 1 and 2 on platelet aggregation. (A, B) The effect of each compound on human platelet aggregation induced by 2 μM U46619 (A) or 1 μg/ml collagen (B). (C) Each compound in DMSO was injected intravenously at the indicated concentration. The effects of each compound on mouse platelet aggregation induced by 2 μM U46619 (U) were monitored ex vivo. D = 0.2% DMSO used as the vehicle control. *P < 0.05 versus U46619 (A, C) or collagen (B) alone.
