Figure 5.

Effects of compounds 1 and 2 on arterial thrombosis and on acute thrombosis. (A) Time to large thrombus formation by compound 1 (white box) and compound 2 (black box). Tirofiban (Tiro) was used as a positive control. (B) The size score of the thrombus at 60 min. after FeCl₃ treatment as described in ‘Materials and methods’. (C) After each compound was injected intravenously, a mixture of collagen (C, 500 μg/kg) plus epinephrine (E, 50 μg/kg) was injected into the tail vein of mice to induce acute thrombosis 6 hrs later. Then, mice (20 mice per group) were carefully examined for 15 min. to determine whether the mouse was paralysed, dead or recovered from the acute thrombotic challenge. D = 0.2% DMSO used as the vehicle control. *P < 0.05 versus DMSO.