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. 2016 Dec 27;21(6):1171–1181. doi: 10.1111/jcmm.13049

Figure 3.

Figure 3

Matrine induces caspase‐3‐dependent apoptosis, following cell cycle arrest. (A) AML cells were treated with 0, 0.75, 1.5, 3 g/l matrine for 24 hrs and stained with Annexin V/PI before being analysed by flow cytometry. (B) AML cells were treated with various concentrations of matrine, and Western blot analysis was performed to assess the cleavage level of PARP and caspase‐3. (C) The cell cycle was analysed using PI staining by flow cytometry in AML cells treated with 0, 0.75, 1.5, 3 g/l matrine for 24 hrs, and the percentage of cells in different phases was presented in bar charts. Results were expressed as mean ± S.E.M. representing at least three independent experiments. *P < 0.05, #P < 0.01, versus the respective control.