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. 2017 May 3;7:1461. doi: 10.1038/s41598-017-01432-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pathways of insulin secretion in pancreas and insulin resistance in liver of DIO zebrafish and T2DM patients. Insulin secretion pathways in (a) DIO zebrafish and (b) pancreatic beta cells of T2DM human patients (GSE20966). Pathways of insulin resistance in (c) DIO zebrafish and (d) human hyperglycaemic liver (GSE23343). Red and blue denote genes with increased and decreased expression, respectively. Grey denotes genes that were not detected in the RNA-seq assay or DNA microarray.