Table 3.
Gene-sets common to the hepatopancreas of DIO zebrafish and hyperglycaemic liver of human type 2 diabetes mellitus patients (GSE23343) according to Gene-Set Enrichment Analysis (GSEA) analysis.
| Category | Name | P value | |
|---|---|---|---|
| DIO-zebrafish | GSE23343 | ||
| Immune response | Humoral immune response | 4.36E-03 | 9.77E-03 |
| B cell apoptotic process | 1.07E-02 | 2.61E-02 | |
| Nervous system | Synaptic transmission | 6.26E-04 | 8.82E-07 |
| Positive regulation of synapse maturation | 1.74E-02 | 2.11E-02 | |
| Vascularization | Artery morphogenesis | 2.39E-02 | 2.50E-02 |
| Homophilic cell adhesion via plasma membrane adhesion molecules | 3.53E-02 | 5.14E-06 | |
| Positive regulation of epithelial cell proliferation | 3.62E-02 | 2.13E-02 | |
| Other | Positive regulation of MAP kinase activity | 8.02E-04 | 1.86E-02 |
| Oxygen transport | 4.55E-02 | 1.60E-02 | |
| Regulation of voltage-gated calcium channel activity | 3.E-02 | 1.E-02 | |