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. 2017 May 3;7:1481. doi: 10.1038/s41598-017-01515-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Foxp3 protects from functional and histological kidney injury in anti-GBM GN. (A) Representative histology sections stained with PAS. Compared with WT normal mouse kidney, severe glomerular crescent formation, segmental glomerular necrosis and tubulointerstitial damage are evident on Day 14 of anti-GBM disease in WT mice. In contrast, histological damage was substantially ameliorated in Foxp3 Tg mice with anti-GBM disease. Glomerular crescents are indicated by arrows. (B) Semi-quantitative analysis of histology. (C) Urinary protein excretion. (D) Plasma creatinine. (E) Creatinine clearance. Each bar represents mean ± SEM. *p < 0.05 and ***p < 0.001 compared with normal mice; ^# p < 0.05, ^## p < 0.01 and ^### p < 0.001 compared with the WT mice. n = 6–8 mice per group. Original magnification X200 (A).