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. 2017 May 3;7:1481. doi: 10.1038/s41598-017-01515-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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T cell-mediated proinflammatory immune response is attenuated in Foxp3 Tg mice with anti-GBM GN. Total kidney RNA was analysed by real-time PCR for the expression of molecules involved in the Th1 response including: (A) T-bet, (B) IFN-γ and the Th2 response such as: (C) GATA3 and (D) IL-4 and the Th17 response such as: (E) RORγt and (F) IL-17A. Levels of immune cytokines in plasma were measured by ELISA. (G) Circulating levels of the Th1 cytokine, IFN-γ. (H) Circulating levels of the Th2-cytokine, IL-4. (I) Circulating levels of the Th17 cytokine, IL-17A. (J) Circulating levels of the immunoregulatory cytokine, TGF-β1. Each bar represents mean ± SEM. **p < 0.01 and ***p < 0.001 compared with normal mice; ^# p < 0.05 and ^## p < 0.01 and ^### p < 0.001 compared with the WT mice. n = 6–8 mice per group.