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. 2017 May 3;7:1477. doi: 10.1038/s41598-017-01550-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity pathway analysis (IPA) showing ROCK2 as one of the direct targets of miRNA-139-5p. miRNA microarray data was subjected to ingenuity pathway analysis (IPA) and various validated targets of miR-139-5p from the literature were plotted as an Interactome. The analysis shows that human ROCK2 is one of the direct targets of miR-139-5p as it has a direct miR-139-5p binding site at its 3′UTR. Some of the other validated targets mentioned in literature, which may also be down-regulated in tonic smooth muscles are given in this interactome.