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. 2017 May 3;7:1472. doi: 10.1038/s41598-017-01650-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Qualitative and quantitative contrast-enhanced ultrasound (CEUS) image and histopathologic image of a 55-year-old female papillary thyroid carcinoma (PTC) patient with extracapsular extension (ECE). (a) Qualitative CEUS image of the patient. The PTC nodule in gray scale ultrasound image was showed by arrow head. The PTC nodule in CEUS image was showed by arrow. (b) Quantitative CEUS image of the patient. Time-intensity curve showed rise time 5.28 sec, peak intensity 4.60 dB, area under the curve 277.65dBsec, time from peak to one half 42.52 sec, wash in slope 0.77dBsec, time to peak 23.71 sec. (c) Histopathologic image revealed PTC of the patient with ECE. The cancer cells were showed by arrow. The thyroid capsule was showed by arrow head. The cancer cells breaked and grew outside the thyroid capsule (original magnification, x100).