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. 2017 May 3;7:1472. doi: 10.1038/s41598-017-01650-2

Figure 4.

Figure 4

Receiver operating characteristic (ROC) curves of contrast-enhanced ultrasound quantitative parameters and tumor size for diagnosis of extracapsular extension (ECE) in papillary thyroid carcinoma. Time from peak to one half (TPH) (area under the curve 0.817, cut-off score 57.97 sec), wash in slope (WIS) (area under the curve o.685, cut-off score 0.64 dB/sec) and tumor size (area under the curve 0.699, cut-off score 7.6 mm). It suggests diagnostic significance of TPH, WIS and tumor size with area under the curve >0.5. The cut off score is choosed as that closest to the point of ROC curves with both highest sensitivity and specificity. A nodule with a measurement above the cut-off score of WIS or tumor size was regarded as ECE, and below the cut-off score of TPH was regarded as ECE.