Table II.
Number of methylated nucleotides in DNA samples from patients with various cervical lesions at each CpG site.
| CpGs | 7,089 | 7,134 | 7,143 | 7,268 | 7,426 | 7,452 | 7,458 | 7,532 | 7,550 | 7,673 | 7,679 | 7,691 | 7,859 | 31 | 37 | 43 | 52 | 58 | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal/LSIL | 6a(30b) | 6 (30) | 5 (30) | 1(30) | 0(30) | 1(30) | 2(30) | 0 (30) | 1 (30) | 1 (30) | 1 (30) | 0 (30) | 1 (37) | 6 (37) | 4 (37) | 5 (37) | 4 (37) | 5 (37) | 49 (582) |
| HSIL | 17 (35) | 11 (35) | 14 (35) | 4 (35) | 4 (35) | 4 (35) | 6 (35) | 3 (31) | 4 (31) | 4 (31) | 2 (31) | 1 (31) | 0 (35) | 7 (35) | 8 (35) | 7 (35) | 8 (35) | 8 (35) | 112 (610) |
| CC | 28 (35) | 23 (35) | 27 (35) | 15 (35) | 14 (35) | 12 (35) | 13 (35) | 2 (30) | 4 (30) | 11 (30) | 5 (30) | 4 (30) | 9 (37) | 24 (37) | 23 (37) | 26 (37) | 26 (37) | 26 (37) | 292 (617) |
| P1 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.002 | 0.009 | 0.238 | 0.339 | 0.002 | 0.161 | 0.061 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| P2 | 0.016 | 0.296 | 0.039 | 0.363 | 0.118 | 0.363 | 0.270 | – | – | 0.354 | – | – | 1.000 | 0.677 | 0.170 | 0.460 | 0.170 | 0.303 | 0.000 |
| P3 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.002 | 0.004 | – | – | 0.001 | – | – | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| P4 | 0.006 | 0.004 | 0.002 | 0.003 | 0.006 | 0.023 | 0.060 | – | – | 0.031 | – | – | 0.002 | 0.000 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
Number of
a
methylated
b
analyzed samples. P1, P-values for χ2 test between normal tissue/LSIL, HSIL and CC. P2, P-values for χ2 test between normal tissue/LSIL and HSIL. P3, P values for χ2 test between normal tissue/LSIL and CC. P4, P-values for χ2 test between HSIL and CC. CpG, cytosine-phosphate-guanine; LSIL, low-grade intraepithelial lesions; HSIL, high-grade intraepithelial lesions; CC, cervical cancer.