Table III.
AUC values obtained from ROC analyses of individual or combined CpG sites.
| CpG site | AUC (95% CI) | Sensitivity, % | Specificity, % | Threshold, % |
|---|---|---|---|---|
| CC vs. normal tissue/LSIL and HSIL | ||||
| 7,089 | 0.782 (0.683–0.881) | 80.0 | 64.6 | 10 |
| 7,143 | 0.796 (0.697–0.895) | 77.1 | 70.8 | 10 |
| 7,089, 7,143 | 0.822 (0.733–0.911) | 77.1 | 73.8 | 15 |
| CC and HSIL vs. normal tissue/LSIL | ||||
| 7,089 | 0.754 (0.660–0.848) | 64.3 | 80.0 | 10 |
| 7,143 | 0.736 (0.640–0.832) | 58.6 | 83.3 | 10 |
| 7,089, 7,143 | 0.787 (0.700–0.874) | 72.9 | 73.3 | 5 |
| CC vs. HSIL | ||||
| 7,089 | 0.726 (0.608–0.844) | 80.0 | 51.4 | 10 |
| 7,143 | 0.753 (0.639–0.868) | 51.4 | 88.6 | 30 |
| 7,089, 7,143 | 0.763 (0.652–0.874) | 77.1 | 62.9 | 15 |
AUC, Area under curve; CI, confidence interval; ROC, receiver operating characteristic; CpG, cytosine-phosphate-guanine; LSIL, low-grade intraepithelial lesions; HSIL, high-grade intraepithelial lesions.