Table IX.

Binomial logistic regression analysis in non-invasive and invasive PA, and the control group.

Gene	PA subgroup	Model	Genotype	OR (95% CI)	P-value	AIC
SIRT1 rs12778366	Non-invasive	Co-dominant	T/T	1.000		390.145
			T/C	0.000 (0.000)	0.996
			C/C	7.571 (3.426–16.426)	<0.001
		Recessive	T/T+T/C	1.000		406.092
			C/C	9.221 (4.175–20.175)	<0.001
		Additive	–	1.649 (1.065–2.065)	0.025	425.148
	Invasive	Co-dominant	T/T	1.000		509.448
			T/C	0.000 (0.000)	0.996
			C/C	7.501 (3.715–15.715)	<0.001
		Recessive	T/T+T/C	1.000		533.418
			C/C	9.136 (4.528–18.528)	<0.001
		Additive	–	1.616 (1.120–2.120)	0.010	459.515
FGFR2 rs2981582	Non-invasive	Co-dominant	G/G	1.000		419.170
			G/A	2.056 (1.136–3.136)	0.017
			A/A	0.000 (0.000)	0.998
		Dominant	G/G	1.000		425.028
			G/A+A/A	1.869 (1.033–3.033)	0.039
		Over-dominant	G/G+A/A	1.000		420.961
			G/A	2.319 (1.283–4.283)	0.005
STAT3 rs744166	Invasive	Co-dominant	A/A	1.000		553.313
			G/A	1.002 (0.630–1.630)	0.993
			G/G	0.210 (0.073–0.073)	0.004
		Recessive	A/A+G/A	1.000		551.313
			G/G	0.210 (0.076–0.076)	0.003
		Additive	–	0.651 (0.467–0.467)	0.011	558.771

PA, pituitary adenoma; SIRT1, sirtuin 1; FGFR2, fibroblast growth factor receptor 2; STAT3, signal transducer and activator of transcription 3; OR, odds ratio; CI, confidence interval; AIC, Akaike Information Criterion.