Table VI.
Frequency of SNPs in patients with PA and in control group according to PA invasiveness.
| Gene marker | Control group, n (%) | P-value HWE | Non invasive PA group, n (%) | P-value HWE | Invasive PA group, n (%) | P-value HWE |
|---|---|---|---|---|---|---|
| SIRT1 rs12778366 | ||||||
| Genotype | ||||||
| T/T | 647 (80.1) | <0.001 | 47 (81.0) | <0.001 | 69 (81.2) | <0.001 |
| T/C | 141 (17.5)a,b | 0 (0.0)a | 0 (0.0)b | |||
| C/C | 20 (2.5)c,d | 11 (19.0)c | 16 (18.8)d | |||
| Total | 808 (100.0) | 58 (100.0) | 85 (100.0) | |||
| Allele | ||||||
| T | 1,435 (88.8) | 94 (81.0) | 138 (81.2) | |||
| C | 181 (11.2) | 22 (19.0) | 32 (18.8) | |||
| FGFR2 rs2981582 | ||||||
| Genotype | ||||||
| G/G | 336 (41.6)e | <0.001 | 16 (27.6)e,f | <0.001 | 40 (47.1)f | 0.043 |
| G/A | 429 (53.1)g | 42 (72.4)g,h | 42 (49.4)h | |||
| A/A | 43 (5.3) | 0 (0.0) | 3 (3.5) | |||
| Total | 808 (100.0) | 58 (100.0) | 85 (100.0) | |||
| Allele | ||||||
| G | 1,101 (68.1) | 74 (63.8) | 122 (71.8) | |||
| A | 515 (31.9) | 42 (36.2) | 48 (28.2) | |||
| STAT3 rs744166 | ||||||
| Genotype | ||||||
| G/G | 154 (19.1)i | <0.001 | 9 (15.5)j | 0.313 | 4 (4.7)i,j | 0.031 |
| G/A | 363 (44.9) | 23 (39.7) | 45 (52.9) | |||
| A/A | 291 (36.0) | 26 (44.8) | 36 (42.4) | |||
| Total | 808 (100.0) | 58 (100.0) | 85 (100.0) | |||
| Allele | ||||||
| G | 671 (41.5) | 41 (35.3) | 53 (31.2) | |||
| A | 945 (58.5) | 75 (64.7) | 117 (68.8) |
SIRT1 rs12778366 T/C genotype is significantly less frequent (P=0.021) in non-invasive PA compared with the control group.
SIRT1 rs12778366 T/C genotype is significantly less frequent (P<0.001) in invasive PA compared with the control group.
SIRT1 rs12778366 C/C genotype is significantly more frequent (P=0.041) in non-invasive PA compared with the control group.
SIRT1 rs12778366 C/C genotype is significantly less frequent (P<0.001) in invasive PA compared with the control group.
FGFR2 rs2981582 G/G genotype is significantly less frequent (P=0.038) in non-invasive PA compared with the control group.
FGFR2 rs2981582 G/G genotype is significantly more frequent (P=0.024) in invasive PA compared with the non-invasive PA group.
FGFR2 rs2981582 G/A genotype is significantly more frequent (P=0.004) in non-invasive PA compared with the control group.
FGFR2 rs2981582 G/A genotype is significantly less frequent (P=0.009) in invasive PA compared with the non-invasive PA group.
STAT3 rs744166 G/G genotype is significantly less frequent (P<0.001) in invasive PA compared with the control group.
STAT3 rs744166 G/G genotype is significantly less frequent (P=0.038) in invasive PA compared with the non-invasive PA group. PA, pituitary adenoma; SIRT1, sirtuin 1, FGFR2, fibroblast growth factor receptor 2; STAT3, signal transducer and activator of transcription 3; HWE, Hardy-Weinberg equilibrium.