Table VI.
Multivariate cox regression analysis of OS and DFS in osteosarcoma patients.
| Disease-free survival | Overall survival | |||
|---|---|---|---|---|
| Category | RR (95% CI) | P-value | RR (95% CI) | P-value |
| Gender (male/female) | – | – | 0.748 (0.428–1.428) | 0.307 |
| Tumor size, cm (≥5.0/<5.0) | 1.324 (0.776–2.776) | 0.314 | 1.810 (0.964–3.964) | 0.065 |
| Clinical stage (IB/III/I+IIA) | 2.607 (1.427–4.427) | 0.002 | 2.243 (1.169–4.169) | 0.015 |
| Distant metastasis (present/absent) | 1.956 (1.091–3.091) | 0.024 | 3.056 (1.514–6.514) | 0.002 |
| Anatomic location (elsewhere/tibia/femur) | 1.443 (0.855–2.855) | 0.169 | 1.119 (0.637–1.637) | 0.696 |
| miR-335 expression (negative/positive) | 0.173 (0.065–0.065) | <0.001 | 0.170 (0.056–0.056) | 0.002 |
| Rock1 expression (positive/negative) | 2.182 (0.917–5.917) | 0.078 | 2.469 (0.903–6.903) | 0.078 |
| miR-335/Rock1 expression | 0.243 (0.073–0.073) | 0.021 | 0.253 (0.064–0.064) | 0.050 |
| (miR-335-low and Rock1-high/others) | ||||
OS, overall survival; DFS, disease free survival; RR, relative risk; CI, confidence interval; miR, microRNA; Rock1, Rho-associated serine-threonine protein kinase 1.