Table I.

Associations between the intratumoral expression levels of IGF-1, IGF-2, IGF-1R and IGFBP-3 genes and the clinicopathological characteristics of patients with colorectal cancer.

	IGF-1 expression			IGF-2 expression			IGF-1R expression			IGFBP-3 expression
Characteristics	Low n=101	High n=101	P-value	Low n=101	High n=101	P-value	Low n=101	High n=101	P-value	Low n=101	High n=101	P-value
Age, years
<60	28	28	1.000	27	29	0.753	30	26	0.530	28	28	1.000
≥60	73	73		74	72		71	75		73	73
Gender
Male	52	58	0.397	51	59	0.258	50	60	0.158	56	54	0.778
Female	49	43		50	42		51	41		45	47
Tumor location
Colon	62	48	0.048	62	48	0.048	54	56	0.778	53	57	0.572
Rectum	39	53		39	53		47	45		48	44
Tumor diameter, cm
≤5	69	62	0.302	73	58	0.027	66	65	0.883	71	60	0.105
>5	32	39		28	43		35	36		30	41
Histological type
Well differentiated	30	29	0.987	30	29	0.668	27	32	0.605	29	30	0.668
Moderately differentiated	57	58		55	60		58	57		60	55
Poorly differentiated	14	14		16	12		16	12		12	16
Depth of invasion
T1	9	8	0.734	9	8	0.781	10	7	0.232	13	4	0.072
T2	19	14		19	14		19	14		18	15
T3	36	42		38	40		32	46		39	39
T4	37	37		35	39		40	34		31	43
Lymph node metastasis
Absent	53	50	0.673	52	51	0.888	48	55	0.325	59	44	0.035
Present	48	51		49	50		53	56		42	57
Lymphatic invasion
Absent	64	68	0.554	64	68	0.554	62	70	0.237	61	71	0.139
Present	37	33		37	33		39	31		40	30
Venous invasion
Absent	41	34	0.308	44	31	0.058	31	44	0.058	43	62	0.109
Present	60	67		57	70		70	57		58	69
Liver metastasis
Absent	83	77	0.298	82	78	0.488	80	80	1.000	84	76	0.165
Present	18	24		19	23		21	21		17	25

IGF, insulin.like growth factor; IGF.1R, IGF receptor type 1; IGFBP.3, IGF binding protein type 3.