Table III.

Univariate and multivariate analyses using the Cox proportional hazard model of variables associated with the postoperative survival of patients with colorectal cancer.

	Univariate analysis			Multivariate analysis
Variables	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Gender
Male vs. female	1.330	0.742–2.742	0.338	–	–	–
Age, years
≥60 vs. <60	1.367	0.695–2.695	0.365	–	–	–
Depth of invasion
T3/4 vs. T1/2	17.687	2.439–128.439	0.004	5.650	0.746–42.746	0.094
Lymph node metastasis
Present vs. absent	6.383	2.979–13.979	<0.001	3.038	1.292–7.292	0.011
Tumor location
Rectum vs. colon	1.513	0.851–2.851	0.158	–	–	–
Lymphatic invasion
Present vs. absent	3.307	1.849–5.849	<0.001	1.604	0.834–3.834	0.157
Venous invasion
Present vs. absent	1.601	0.827–3.827	0.163	–	–	–
Liver metastasis
Present vs. absent	7.258	4.033–13.033	<0.001	4.695	2.511–8.511	<0.001
Histological type
Moderate and poor vs. well	2.045	0.955–4.955	0.066	–	–	–
Tumor diameter, cm
≤5 vs. >5	2.191	1.236–3.236	0.007	1.225	0.677–2.677	0.502
IGF-1 expression level
High vs. low	1.340	0.754–2.754	0.319	–	–	–
IGF-2 expression level
High vs. low	1.645	0.914–2.914	0.097	–	–	–
IGF-1R expression level
High vs. low	1.130	0.635–2.635	0.677	–	–	–
IGFBP-3 expression level
High vs. low	2.439	1.320–4.320	0.004	2.033	1.087–3.087	0.026

IGF-1, insulin-like growth factor type 1; IGF-1R, IGF receptor type 1; IGFBP-3, IGF binding protein type 3; CI, confidence interval.