Figure 5.
Effects of CoCl2-induced hypoxia on the production of angiogenic/inflammatory proteins in B16.F10 melanoma cells. Results are presented either as a percentage of reduction in tumor protein levels ranging from 0% (white) to 100% (black), or as percentage of increase in protein production ranging from 0% (white with vertical line pattern) to 100% (black with vertical line pattern) in cells treated with CoCl2 compared with the levels of the same proteins in normoxic cells. Hypoxic cells, percentages of protein expression levels in B16.F10 melanoma cells after incubation with 200 µM CoCl2 for 24 h compared with their levels in normoxic cells; G-CSF, granulocyte-colony stimulating factor; M-CSF, macrophage-colony stimulating factor; IGF, insulin-like growth factor; IL, interleukin; TNF, tumor necrosis factor; FasL, Fas ligand; bFGF, basic fibroblast growth factor; VEGF, vascular endothelial growth factor; TIMP, tissue inhibitor of metalloproteinase; IFN, interferon.