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. 2017 Mar 23;13(5):3387–3394. doi: 10.3892/ol.2017.5895

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effects of TYMS expression in HCT116 and HT29 cells. (A) TYMS siRNA decreased the expression level of TYMS in HCT116 and HT29 cells. (B) Cell growth was suppressed in TYMS siRNA transfected HCT116 and HT29 cells compared with the NC siRNA groups. (C) Chemosensitivity assays demonstrated that TYMS siRNA enhanced the chemosensitivity of HCT116 and HT29 cells to 5-FU. (D) Inhibition of TYMS increased apoptosis of HCT116 and HT29 cells induced by 5-FU. *P<0.05 compared with the NC. TYMS, thymidylate synthase; siRNA, short interfering RNA; NC, negative control; 5-FU, 5-fluorouracil.