Table IV.

Assessment of serum hs-CRP, AFP and CRP+AFP in the diagnosis of hepatocellular carcinoma.

Parameter	AUC	Sensitivity, %	Specificity, %	PPV, %	NPV, %
AFP	0.824	74.42	55.63	51.60	89.00
CRP	0.903	84.16	61.59	59.44	85.32
CRP+AFP	0.998	94.06	37.75	81.36	90.00

The diagnostic cutoff values of serum CRP and AFP were 2.17 mg/l and 20 ng/l, respectively. hs-CRP, high-sensitivity C-reactive protein; AFP, α-fetoprotein; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value.