Table III.
Associations between LF and survival.
| Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|
| Variables | Patients, n | Succumbed to disease, n (%) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age, years | 0.120 | 0.007a | 0.004a | ||||
| ≤70 | 33 | 10 (30) | 1.0 | 1.0 | |||
| >70 | 32 | 18 (56) | 2.6 (1.2–5.2) | 3.3 (1.4–7.4) | |||
| pT | 0.070 | 0.030a | 0.008a | ||||
| 1 | 36 | 11 (31) | 1.0 | 1.0 | |||
| 2 | 21 | 11 (52) | 1.7 (0.7–3.7) | 1.0 | |||
| 3 | 2 | 1 (50) | 2.1 (0.1–24.1) | 1.0 | |||
| 4 | 6 | 5 (83) | 4.3 (0.8–20.8) | 4.4 (1.4–13.4) | |||
| pN | 0.620 | 0.340 | |||||
| N0 | 35 | 14 (40) | 1.0 | ||||
| N+ | 30 | 14 (47) | 1.4 (0.6–3.6) | ||||
| Histological grade | 0.300 | 0.120 | |||||
| 2 | 24 | 8 (33) | 1.0 | ||||
| 3 | 41 | 20 (49) | 1.8 (0.8–3.8) | ||||
| Ki-67 LI | 0.150 | 0.610 | 0.04a | ||||
| Low (≤20%) | 31 | 12 (39) | 1.0 | 0.3 (0.1–0.1) | |||
| High (>20%) | 34 | 16 (47) | 1.2 (0.5–2.5) | 1.0 | |||
| LF expression | 0.020a | 0.060a | |||||
| Absent | 48 | 25 (52) | 2.9 (1.2–6.2) | ||||
| Present | 17 | 3 (18) | 1.0 | ||||
a
P<0.05. LI, labeling index; LF, lactoferrin; pT, pathological tumor; pN, pathological node; HR, hazard ratio; CI, confidence interval.