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. 2016 Dec 5;6:11. doi: 10.1038/s41598-016-0013-4

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© The Author(s) 2016

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Results of dose response study of primary HTS hits against the panel of metzincins. (A) HPLC-based assays of CID 3117694 against ADAM10 and 17 using glycosylated substrate. (B) Screening of CID 3117694 against a panel of metzincins. (C) Screening of CID 730037 against a panel of metzincins. (D) Screening of CID 3153587 against a panel of metzincins. (E) Screening of CID 236330 against a panel of metzincins.