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. 2016 Dec 5;6:11. doi: 10.1038/s41598-016-0013-4

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© The Author(s) 2016

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Mechanism of CID 3117694 inhibition of ADAM10. (A) Plot of K_obs versus [I] for CID 3117694 inhibition of ADAM10. Please note the hyperbolic relationship between k_obs and [I] suggesting that inhibitor binding complies with the two-step model. (B) Plot of K_obs versus [S]/K_M for CID 3117694 inhibition of ADAM10. Please note k_obs decreases with increase of [S]/K_M suggesting that inhibitor competes with a substrate. (C) Dose response study of ADAM10 inhibition by AHA alone and in the presence of varying dose of CID 3117694. Please note that AHA IC₅₀ decreases significantly in the presence of CID 3117694. (D) Normalized isobologram of two drug combination effect on ADAM10 activity. Please note that majority of AHA-CID 3117694 combinations produced synergistic effect as compared to a single drug application.