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. 2016 Dec 5;6:11. doi: 10.1038/s41598-016-0013-4

Figure 5.

Figure 5

Inhibition of shedding of HER2, CXCL16 and syndecan by CID 3117694. (A) Effect of CID 3117694 on viability of BT474 breast cancer cells and HEK293 cells. Please note that only 100 µM of CID 3117694 has moderate effect on HEK293 cell viability. (B) Inhibition of HER2 shedding in BT474 cells by CID 3117694. One-way analysis of variance (ANOVA) was used followed by Dunnett post hoc test. The data shown are the mean ± SEM, n = 3 from 3 independent experiments. *****p value < 0.0001, ***p value < 0.001, **p value < 0.01, *p value < 0.05; GI–control inhibitor of ADAM10 and MMPs GI254023X; (C) Results of CXCL16 ELISA assay in A549 lung cancer cells. The data shown are the mean ± SEM, n = 3 from 3 independent experiments. One-way analysis of variance (ANOVA) was used followed by Dunnett post hoc test. *****p value < 0.0001, ***p value < 0.001, **p value < 0.01, *p value < 0.05; all compared to DMSO TI. (D) Results of syndecan-4 dot blot assay (blot representative of three independent experiments shown).