. 2016 Dec 19;6:13. doi: 10.1038/s41598-016-0006-3

Table 5.

Quantitative levels of NPC circulating biomarkers in 28 matched samples.

Patient ID	AJCC 7^th Stage	Post-Treatment Radiological Response	Status on Follow-up	BamHI-W qPCR Assay (copies/mL)		EBNA1-qPCR Assay (copies/mL)		EBNA1-dPCR Assay (copies/mL)		Canonical CTCs (cells/mL)		Potential CTCs (cells/mL)
Patient ID	AJCC 7^th Stage	Post-Treatment Radiological Response	Status on Follow-up	Pre-Treatment	Post-Treatment	Pre-Treatment	Post-Treatment	Pre-Treatment	Post-Treatment	Pre-Treatment	Post-Treatment	Pre-Treatment	Post-Treatment
006	I	CR	NED	0	0	0	0	0	0	4	3	13	88
014	I	CR	NED	0	0	0	0	0	0	1	5	12	5
024	I	PR	NED	0	0	49	0	0	0	31	1	63	3
007	I	CR	NED	21	0	0	0	9	0	0	0	20	103
008	I	CR	NED	107	0	0	0	0	0	0	3	14	14
019	I	nCR	NED	162	42	0	0	13	0	18	22	44	148
028	I	CR	NED	360	0	0	0	53	14	1	0	7	13
017	II	PR	NED	67	0	0	0	21	7	50	16	134	220
032	II	PR	NED	92	0	0	0	42	7	3	0	67	15
035	II	nCR	NED	146	0	21	0	0	0	1	0	14	23
013^b	II	CR	NED	301	0	0	0	28	0	0	3	0	26
011^b	II	CR	NED	23,507	27	2,838	0	3,656	0	2	6	1	9
004^b	III	CR	NED	507	0	30	0	43	0	0	4	0	26
021^b	III	nCR	NED	1,236	0	33	0	49	0	37	2	76	33
029^b	III	nCR	NED	6,072	0	303	0	816	0	17	0	47	6
027^b	III	CR	NED	6,687	0	431	0	1,356	0	4	1	21	18
030^b	III	nCR	NED	8,226	0	714	0	1,095	0	0	0	15	0
002^b	III	nCR	NED	9,728	0	385	0	1,109	7	0	0	12	150
003^b	III	CR	NED	10,631	0	855	0	1,376	0	NA	NA	NA	NA
009	III	PD	DOD	18,572	131	5,425	0	3,636	35	NA	NA	NA	NA
001^b	III	CR	NED	70,569	0	5,416	0	9,484	0	NA	NA	NA	NA
023^b	III	CR	NED	29,006	47	777	0	3,272	6	NA	NA	NA	NA
022^b	III	nCR	NED	44,918	0	1,964	0	3,949	13	NA	NA	NA	NA
026^b	IV	PR	NED	1,157	0	121	0	230	7	16	2	83	6
010^b	IV	PR	AWD	1,249	0	36	0	132	0	3	0	4	3
005^b	IV	nCR	NED	1,324	0	80	0	168	0	5	1	13	27
012^b	IV	PR	DOD	99,379	24,577	18,816	2,529	14,199	5,107	6	1	146	35
018^b	IV	PR	NED	441,316	0	13,565	0	50,081	0	11	6	29	61
Mean				27,690	887	1852	90	3,386	186	9	3	36	45
P-Values^a				<0.001		<0.007		<0.001		0.07		0.54

Abbreviations: NPC, nasopharyngeal carcinoma; AJCC, American Joint Committee on Cancer; CTCs, circulating tumour cells; nCR, near complete response; CR, complete response; PR, partial response; PD, progressive disease; NED, no evidence of disease; AWD, alive with disease; DOD, dead of disease; NA, data are not available

^aP-Values were calculated using the Wilcoxon’s signed rank testing and values < 0.05 were considered statistically significant.

^bPatients undergoing chemo-radiotherapy.