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. 2017 Mar 13;13(5):2867–2872. doi: 10.3892/ol.2017.5851

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Amino acid sites of phosphorylation and acetylation of human FOXO3a. The different colors represent different kinases for FOXO3a modification and different regions of FOXO3a protein. A, B and C represent different sections of CR2. MST1, mammalian sterile 20-like kinase 1; AKT, protein kinase B; SGK, serum and glucocorticoid-induced kinase; AMPK, AMP-activated protein kinase; ERK, extracellular signal-regulated kinase; LMTK, lemur tyrosine kinase; CK1, casein kinase-1; JNK, c-Jun N-terminal kinase; IKK, IκB kinase; CBP, cyclic AMP response element binding protein; SIRT, silent information regulator; CR, conserved region; FH, forkhead; NLS, nuclear localization signal; NES, nuclear export signal; S, serine; T, threonine; K, lysine.