Figure 3.

MTE reduces neovascularization. Solid tumors were induced in female BALB/c mice by injecting A20 cells subcutaneously into the right forelimb region. (A) A daily intraperitoneal injection of 300 µl MTE for 7 consecutive days was administered to the tumor-bearing mice. When a tumor mass was detectable visually, tumor tissues were excised and images of the peritumorous blood vessel were captured. (B) Representative photomicrographs showing the hematoxylin and eosin staining of A20 tumor tissue sections in control and MTE-treated mice (x200 magnification). Bar, 10 µm. (C) The microvessel density (x200 magnification). Results are expressed as the mean ± standard deviation from two independent experiments. *P<0.05 vs. control. MTE. Marsdenia tenacissima extract.