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. 2017 May 4;7:1513. doi: 10.1038/s41598-017-01587-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Photomicrograph of phosphorylated tau immunohistochemistry of the temporal lobe of the GRN mutation cases. Massive AT8-positive structures were observed in the hippocampus (A), amygdala (B), inferior temporal cortex (C) in case 2. AT8-positive astrocytes were observed in the temporal cortex (D) and AT8-positive oligodendrocytes in the white matter of temporal lobe (E) in case 2. AT8-positive deposition was also detected in amygdala in case 1 (F), hippocampus in case 3 (G) and entorhinal cortex in case 4 (H). The sections were counterstained with Kernechtrot stain solution. The scale bar in A applies to (B,C,D,F,G and H) (200 μm), in E (100 μm), respectively. The scale bars in the inserts are 50 μm (C and D) and 25 μm (E), respectively.