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. 2017 May 4;7:1498. doi: 10.1038/s41598-017-01659-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cryptolepine treatment inhibits the viability and growth of melanoma cells. (a) Treatment of melanoma cells (A375, SK-Mel28, SK-Mel119 and Hs294t) and normal human epidermal melanocytes with cryptolepine (0, 1.0, 2.5, 5.0 and 7.5 µM) for 24 or 48 h inhibits cell viability in a dose- and time-dependent manner. Cell viability was determined using an MTT assay as described in the Materials and Methods. Cells were seeded in 96-well plates in 6 replicates/sample and per treatment group. Cells treated with DMSO alone served as a vehicle control. Statistical significance versus control group, *P < 0.05, ^¶ P < 0.01, ^† P < 0.001. (b) Effect of cryptolepine on the colony forming capacity of melanoma cells. Colonies were detected by staining with crystal violet and plates were scanned for photographs. Colonies appear blue-violet.