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. 2017 May 4;7:1498. doi: 10.1038/s41598-017-01659-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with cryptolepine disrupts mitochondrial membrane potential in melanoma cells. (a) Representative melanoma cell lines (A375 and Hs294t) were treated with various concentrations of cryptolepine (0, 2.5, 5.0 and 7.5 µM) for 24 h. Thereafter, cells were harvested, incubated with Rhodamine 123 and then analyzed for loss of mitochondrial disruption using flow cytometry. Data were compared with non-cryptolepine-treated cells. Treatment groups are shown in color. (b) Percentage of cells with mitochondrial disruption in different treatment groups was determined. The resultant data are presented in terms of the percentage of cells with loss of mitochondrial membrane potential and as means ± SD, n = 3. Statistical difference versus control, *P < 0.05 and ^¶ P < 0.01.