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. 2017 May 8;7:1526. doi: 10.1038/s41598-017-01207-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of pooled datasets of lung cancer. (A) Evaluation in KM-plotter shows that DDIT4 expression (cutoff over the median) is not related with the free progression time; however (B) in 5-years censored data stratified in the upper tertile, high DDIT4 expression is related with PF [N = 982; P = 0.04] (C) Overall survival analysis show that DDIt4 expression over the median is related with a poor outcome (P = 0.015), (D) increasing the significance when data is 5-years censored and stratified by the upper tertile. Meta-analysis in SurvExpress show DDIT4 expression over the median increases the (E) risk of recurrence by 35% and (F) the risk of death by 24%.